abstract：:It has been proposed that normal waking levels of acetylcholine (ACH) are important for initial memory acquisition, and that decreased ACH is critical for memory consolidation. Sleep is thought to benefit memory consolidation in part due to the predominance of low ACH levels observed during non-rapid eye movement slee...

journal_title：Neurobiology of learning and memory

authors： Tucker MA,Taylor K,Merchant R,George S,Stoddard C,Kopera K

更新日期：2018-11-01 00:00:00

abstract：:Accumulating evidence indicates that homeostatic plasticity mechanisms dynamically adjust synaptic strength to promote stability that is crucial for memory storage. Our previous studies have shown that prior training in conditioned taste aversion (CTA) prevents the subsequent induction of long-term potentiation (LTP) ...

journal_title：Neurobiology of learning and memory

authors： Rivera-Olvera A,Nelson-Mora J,Gonsebatt ME,Escobar ML

更新日期：2018-10-01 00:00:00

abstract：:Evidence is reviewed that behavioral training and neural injury can engage metaplastic processes that regulate adaptive potential. This issue is explored within a model system that examines how training affects the capacity to learn within the lower (lumbosacral) spinal cord. Response-contingent (controllable) stimula...

journal_title：Neurobiology of learning and memory

authors： Grau JW,Huang YJ

更新日期：2018-10-01 00:00:00

abstract：:Variance in spatial abilities are thought to be determined by in utero levels of testosterone and oestrogen, measurable in adults by the length ratio of the 2nd and 4th digit (2D:4D). We confirmed the relationship between 2D:4D and spatial performance using rats in two different tasks (paired-associate task and waterm...

journal_title：Neurobiology of learning and memory

authors： Müller N,Campbell S,Nonaka M,Rost TM,Pipa G,Konrad BN,Steiger A,Czisch M,Fernández G,Dresler M,Genzel L

更新日期：2018-05-01 00:00:00

abstract：:Over the last decade, the interest in transcranial direct current stimulation (tDCS) has continued to increase, along with consideration of how it affects neuroplasticity mechanisms in the brain. Both human and animal studies have demonstrated numerous benefits and, although its application has increased, the neurophy...

journal_title：Neurobiology of learning and memory

authors： Stafford J,Brownlow ML,Qualley A,Jankord R

更新日期：2018-04-01 00:00:00

abstract：:MeCP2 is required both during postnatal neurodevelopment and throughout the adult life for brain function. Although it is well accepted that MeCP2 in the maturing nervous system is critical for establishing normal development, the functions of MeCP2 during adulthood are poorly understood. Particularly, the requirement...

journal_title：Neurobiology of learning and memory

authors： Gulmez Karaca K,Brito DVC,Zeuch B,Oliveira AMM

更新日期：2018-03-01 00:00:00

abstract：:Intrauterine adverse conditions may be responsible for long-lasting damages which impact health even during adult phase. Hypoxic-ischemic (HI) events are a relevant cause of newborn mortality and the principal factor leading to permanent brain lesions. Using a model in which the ovarian and uterine flux of a pregnant ...

journal_title：Neurobiology of learning and memory

authors： Cunha-Rodrigues MC,Balduci CTDN,Tenório F,Barradas PC

更新日期：2018-03-01 00:00:00

abstract：:The therapeutic efficacy of the synthetic β-adrenergic receptor blocker, propranolol, for the treatment of post-traumatic stress disorder (PTSD) is currently being debated. Mixed results have been published regarding propranolol's ability to disrupt the consolidation and reconsolidation of memories. Here, we use the i...

journal_title：Neurobiology of learning and memory

authors： Shymansky T,Hughes E,Rothwell CM,Lukowiak K

更新日期：2018-03-01 00:00:00

abstract：:Chronic stress leads to a dysregulated inhibitory tone that could impact hippocampal-dependent spatial learning and memory. The present study examined whether spatial memory deficits resulting from chronic stress could be overcome by antagonizing the GABAA receptor, a prominent inhibitory receptor of GABA in the hippo...

journal_title：Neurobiology of learning and memory

authors： Nishimura KJ,Ortiz JB,Conrad CD

更新日期：2017-11-01 00:00:00

abstract：:Addiction is increasingly discussed asa disorder of associative learning processes, with both operant and classical conditioning contributing to the development of maladaptive habits. Stress has long been known to promote drug taking and relapse and has further been shown to shift behavior from goal-directed actions t...

journal_title：Neurobiology of learning and memory

authors： Ehlers MR,Todd RM

更新日期：2017-11-01 00:00:00

abstract：:Aiming at exploring the brain's structural organisation underlying successful second language learning, we investigate the anatomy of the perisylvian language network in a group of healthy adults, consisting of participants with high and average language analytical abilities. Utilising deterministic tractography, six ...

journal_title：Neurobiology of learning and memory

authors： Kepinska O,Lakke EAJF,Dutton EM,Caspers J,Schiller NO

更新日期：2017-10-01 00:00:00

abstract：:Every learning event is embedded in a context, but not always does the context become an integral part of the memory; however, for extinction learning it usually does, resulting in context-specific conditioned responding. The neuronal mechanisms underlying contextual control have been mainly investigated for Pavlovian...

journal_title：Neurobiology of learning and memory

authors： Starosta S,Bartetzko I,Stüttgen MC,Güntürkün O

更新日期：2017-10-01 00:00:00

abstract：:Carriers of a FMR1 premutation allele (between 55 and 199 CGG repeats) are at risk of developing a wide range of medical, psychiatric and cognitive disorders, including executive dysfunction. These cognitive deficits are often less severe for female premutation carriers compared to male premutation carriers, albeit si...

journal_title：Neurobiology of learning and memory

authors： Shelton AL,Cornish K,Fielding J

更新日期：2017-10-01 00:00:00

abstract：:Relapse to drug use is often precipitated by exposure to drug associated cues that evoke craving. Cue-induced drug craving has been observed in both animals and humans to increase over the first few weeks of abstinence and remain high over extended periods, a phenomenon known as 'incubation of craving'. As adolescence...

journal_title：Neurobiology of learning and memory

authors： Madsen HB,Zbukvic IC,Luikinga SJ,Lawrence AJ,Kim JH

更新日期：2017-09-01 00:00:00

abstract：:It is currently well established that the synthesis of new proteins (mRNA translation) is required for long-lasting synaptic plasticity and memory formation. Translation in the brain is regulated primarily at the initiation stage by general as well as by gene-specific mechanisms. Stored memories can become sensitive t...

journal_title：Neurobiology of learning and memory

authors： Roesler R

更新日期：2017-07-01 00:00:00

abstract：:Numerous experiments using ex vivo electrophysiology suggest that mammalian learning and memory involves regulation of voltage-gated ion channels in terms of changes in function. Yet, little is known about learning-related regulation of voltage-gated ion channels in terms of changes in expression. In two experiments, ...

journal_title：Neurobiology of learning and memory

authors： Fuchs JR,Darlington SW,Green JT,Morielli AD

更新日期：2017-07-01 00:00:00

abstract：:Brief physical exercise enhances memories for neutral events, and recently has been shown to modulate fear learning in animals. To date there is no evidence pertaining to the impact of exercise on emotional memories in humans. Accordingly, this study investigated the role of brief exercise in the development of emotio...

journal_title：Neurobiology of learning and memory

authors： Keyan D,Bryant RA

更新日期：2017-05-01 00:00:00

abstract：:The pond snail Lymnaea stagnalis is capable of learning taste aversion by pairing presentations of a sucrose solution and an electric shock and consolidating it into long-term memory (LTM), which is referred to as conditioned taste aversion (CTA). We asked here if the neurotransmitter octopamine is involved in CTA. We...

journal_title：Neurobiology of learning and memory

authors： Aonuma H,Kaneda M,Hatakeyama D,Watanabe T,Lukowiak K,Ito E

更新日期：2017-05-01 00:00:00

abstract：:It is well established that neurons are plastic and can change the strength of their connections with other neurons depending on their recent history. While many molecular entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not kno...

journal_title：Neurobiology of learning and memory

authors： Tshuva RY,Korkotian E,Segal M

更新日期：2017-04-01 00:00:00

abstract：:Down syndrome (DS) is a common genetic cause of intellectual disability yet no pro-cognitive drug therapies are approved for human use. Mechanistic studies in a mouse model of DS (Ts65Dn mice) demonstrate that impaired cognitive function is due to excessive neuronal inhibitory tone. These deficits are normalized by ch...

journal_title：Neurobiology of learning and memory

authors： Colas D,Chuluun B,Garner CC,Heller HC

更新日期：2017-04-01 00:00:00

abstract：:The long-lasting effects of gestational cannabinoids exposure on the adult brain of the offspring are still controversial. It has already been shown that pre- or perinatal cannabinoids exposure induces learning and memory disruption in rat adult offspring, associated with permanent alterations of cortical glutamatergi...

journal_title：Neurobiology of learning and memory

authors： Beggiato S,Borelli AC,Tomasini MC,Morgano L,Antonelli T,Tanganelli S,Cuomo V,Ferraro L

更新日期：2017-03-01 00:00:00

abstract：:Renewal, or reinstatement, of responding to food cues after extinction may explain the inability to resist palatable foods and change maladaptive eating habits. Previously, we found sex differences in context-dependent renewal of extinguished Pavlovian conditioned responding to food cues. Context-induced renewal invol...

journal_title：Neurobiology of learning and memory

authors： Anderson LC,Petrovich GD

更新日期：2017-03-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need f...

journal_title：Neurobiology of learning and memory

authors： Shafia S,Vafaei AA,Samaei SA,Bandegi AR,Rafiei A,Valadan R,Hosseini-Khah Z,Mohammadkhani R,Rashidy-Pour A

更新日期：2017-03-01 00:00:00

abstract：:The unique polarity of neurons requires that synaptic inputs are relayed to the nucleus to trigger changes in gene expression. This long distance signaling process is crucial for the function and survival of neuronal circuits. To that end, neurons have developed multiple modes of signal transmission from the synapse t...

journal_title：Neurobiology of learning and memory

authors： Lim AF,Lim WL,Ch'ng TH

更新日期：2017-02-01 00:00:00

abstract：:Abstinent alcohol-dependent individuals experience an enduring sensitivity to cue-induced craving and relapse to drinking. There is considerable evidence indicating that structures within the midbrain and extended amygdala are involved in this process. Individually, the ventral tegmental area (VTA) and the bed nucleus...

journal_title：Neurobiology of learning and memory

authors： Pina MM,Cunningham CL

更新日期：2017-01-01 00:00:00

abstract：:Activity in the rodent prelimbic (PL) cortex contributes to consolidation, retrieval and reconsolidation of learned fear. The PL cortex is considered homologous to the primate dorsal anterior cingulate cortex (dACC). In patients with post-traumatic stress disorder (PTSD), the dACC is often reported to be hyperactive a...

journal_title：Neurobiology of learning and memory

authors： Vanvossen AC,Portes MAM,Scoz-Silva R,Reichmann HB,Stern CAJ,Bertoglio LJ

更新日期：2017-01-01 00:00:00

abstract：:Whether or not spatial memories reorganize in the rodent brain is an unanswered question that carries the importance of whether the rodent provides a suitable animal model of human retrograde amnesia. The finding of equally impaired recent and remote spatial memory could reflect the continued importance of the hippoca...

journal_title：Neurobiology of learning and memory

authors： Hales JB,Ocampo AC,Broadbent NJ,Clark RE

更新日期：2016-12-01 00:00:00

abstract：:Anxiety disorders and obesity are both common in youth and young adults. Despite increasing evidence that over-consumption of palatable high-fat/high-sugar "junk" foods leads to adverse neurocognitive outcomes, little is known about the effects of palatable diets on emotional memories and fear regulation. In the prese...

journal_title：Neurobiology of learning and memory

authors： Baker KD,Reichelt AC

更新日期：2016-12-01 00:00:00

abstract：:Mixed results with the synthetic β-adrenergic receptor blocker, propranolol, have been reported in human populations with regards to its therapeutic efficacy for PTSD treatments targeting the memory reconsolidation process. Stress alters the ability to form and maintain memory, but whether the causal neuronal mechanis...

journal_title：Neurobiology of learning and memory

authors： Hughes E,Shymansky T,Sunada H,Lukowiak K

更新日期：2016-12-01 00:00:00

abstract：:Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in diff...

journal_title：Neurobiology of learning and memory

authors： Masuda A,Kobayashi Y,Kogo N,Saito T,Saido TC,Itohara S

更新日期：2016-11-01 00:00:00

abstract：:The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) affects numerous behavioral and physiological processes. Drugs that alter 5-HT signaling treat several major psychiatric disorders and may lead to widespread abuse. The dorsal raphe nucleus (DRN) in the midbrain provides a majority of 5-HT for the forebrain. T...

journal_title：Neurobiology of learning and memory

authors： Luo M,Li Y,Zhong W

更新日期：2016-11-01 00:00:00

abstract：:Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female r...

journal_title：Neurobiology of learning and memory

authors： Fenton GE,Halliday DM,Mason R,Bredy TW,Stevenson CW

更新日期：2016-11-01 00:00:00

abstract：:Regional differences in large-scale connectivity have been proposed to underlie functional specialization along the anterior-posterior axis of the medial temporal lobe (MTL), including the hippocampus (HC) and the parahippocampal gyrus (PHG). However, it is unknown whether functional connectivity (FC) can be used reli...

journal_title：Neurobiology of learning and memory

authors： Wang SF,Ritchey M,Libby LA,Ranganath C

更新日期：2016-10-01 00:00:00

abstract：:Recent models of hippocampal function have emphasized its role in relational binding - the ability to form lasting representations regarding the relations among distinct elements or items which can support memory performance, even over brief delays (e.g., several seconds). The present study examined the extent to whic...

journal_title：Neurobiology of learning and memory

authors： Rondina R 2nd,Olsen RK,McQuiggan DA,Fatima Z,Li L,Oziel E,Meltzer JA,Ryan JD

更新日期：2016-10-01 00:00:00

abstract：:Human studies of sleep and cognition have established thatdifferent sleep stages contribute to distinct aspects of cognitive and emotional processing. However, since the majority of these findings are based on single-night studies, it is difficult to determine whether such effects arise due to individual, between-subj...

journal_title：Neurobiology of learning and memory

authors： Lerner I,Lupkin SM,Corter JE,Peters SE,Cannella LA,Gluck MA

更新日期：2016-10-01 00:00:00

abstract：:Cognitive impairments are amongst the most debilitating deficits of schizophrenia and the best predictor of functional outcome. Schizophrenia is hypothesized to have a neurodevelopmental origin, making animal models of neurodevelopmental insult important for testing predictions that early insults will impair cognitive...

journal_title：Neurobiology of learning and memory

authors： O'Reilly KC,Perica MI,Fenton AA

更新日期：2016-10-01 00:00:00

abstract：:Veridical detection of safety versus danger is critical to survival. Learned signals for safety inhibit fear, and so when presented, reduce fear responses produced by danger signals. This phenomenon is termed conditioned inhibition of fear. Here, we report that CS+/CS- fear discrimination conditioning over 5 days in r...

journal_title：Neurobiology of learning and memory

authors： Foilb AR,Flyer-Adams JG,Maier SF,Christianson JP

更新日期：2016-10-01 00:00:00

abstract：:Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippo...

journal_title：Neurobiology of learning and memory

authors： Krawczyk MC,Navarro N,Blake MG,Romano A,Feld M,Boccia MM

更新日期：2016-09-01 00:00:00

abstract：:The neurosteroid pregnenolone (PREG) has been shown to have memory-enhancing and anti-depressant action. The present study addresses the question of whether intranasally applied pregnenolone (IN-PREG) also has promnestic properties in the rat. We examined the effects of IN-PREG at doses of 0.187 and 0.373mg/kg on memo...

journal_title：Neurobiology of learning and memory

authors： Abdel-Hafiz L,Chao OY,Huston JP,Nikolaus S,Spieler RE,de Souza Silva MA,Mattern C

更新日期：2016-09-01 00:00:00

abstract：:Drug abuse, overeating, and smoking are all examples of instrumental behaviors that often involve chains or sequences of behavior. A behavior chain is minimally composed of a procurement response that is required in order for a subsequent consumption response to be reinforced. Despite the translational importance of b...

journal_title：Neurobiology of learning and memory

authors： Thrailkill EA,Bouton ME

更新日期：2016-09-01 00:00:00